| 大豆磷脂对小鼠酒精性肝损伤的保护作用 |
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| 引用本文： | 康东周,赵莲芳,全仙花.大豆磷脂对小鼠酒精性肝损伤的保护作用[J].延边医学院学报,2006,29(1):42-44. |
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| 作者姓名： | 康东周 赵莲芳 全仙花 |
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| 作者单位： | [1]延边大学药学院 [2]延边大学护理学院 [3]延边中医医院,吉林延吉133000 |
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| 摘 要： | 目的]研究大豆磷脂对小鼠酒精性肝损伤的保护作用.方法]建立小鼠酒精性肝损伤模型,设空白对照组、肝损伤模型组和大豆磷脂小、中、大剂量(0.12,0.24,0.48 g/kg)组,给予相应处理7 d后测定血清中ALT,AST含量和肝匀浆液中MDA,GSH含量.结果]大豆磷脂大剂量组小鼠血清中ALT含量及中、大剂量大豆磷脂组小鼠血清中AST含量均较肝损伤模型组低,大豆磷脂各剂量组小鼠肝组织内MDA含量显著低于肝损伤模型组,大豆磷脂大剂量组小鼠肝组织内GSH含量明显高于肝损伤模型组.结论]大豆磷脂对酒精性肝损伤具有保护作用.
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| 关 键 词： | 肝疾病 酒精性 植物 药用 小鼠 |
| 文章编号： | 1000-1824（2006）01-0042-02 |
| 收稿时间： | 2005-07-12 |
| 修稿时间： | 2005年7月12日 |
Protective effects of soybean phosphorlipid on ethanol-induced hepatotoxicity in mice |
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| KANG Dong-zhou,ZHAO Lian-fang,QUAN Xian-hua.Protective effects of soybean phosphorlipid on ethanol-induced hepatotoxicity in mice[J].Journal of Medical Science Yanbian University,2006,29(1):42-44. |
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| Authors: | KANG Dong-zhou ZHAO Lian-fang QUAN Xian-hua |
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| Abstract: | OBJECTIVE To study the protective effects of soybean phosphorlipid on ethanol-induced(hepatotoxicity) in mice. METHODS The liver injury models were induced by ethanol in mice,and were(randomly) divided into 5 groups: control,liver injury control and low,middle,high dosage of soybean(phosphorlipid) groups.After 7 days,the contents of ALT and AST in(serum and) the MDA and GSH in liver(tissue) were (measured.) RESULTS Compared with liver injury control group,the contents of ALT in high dosage of soybean phosphorlipid group and the AST in middle and high dosage of soybean phosphorlipid groups were(decreased) in serum,the content of MDA in low,middle,high dosage of soybean phosphorlipid groups were(decreased) in liver tissue,and the content of GSH in high dosage of soybean phosphorlipid group was increased in liver tissue. CONCLUSION The soybean phosphorlipid has the protective effects on liver injuries induced by ethanol in mice. |
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| Keywords: | liver diseases alcoholic plants medicinal mice |
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