| 冠心病患者血清同型半胱氨酸、miR-1、miR-126和 miR-208的相关性分析 |
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| 引用本文： | 金洁,;王俊,;王磊,;蔡晓敏,;王立军,;宫剑滨.冠心病患者血清同型半胱氨酸、miR-1、miR-126和 miR-208的相关性分析[J].东南国防医药,2014(4):363-366. |
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| 作者姓名： | 金洁 ;王俊 ;王磊 ;蔡晓敏 ;王立军 ;宫剑滨 |
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| 作者单位： | [1]空军杭州航空医学鉴定训练中心内科,浙江杭州310007; [2]南京大学医学院南京军区南京总医院心脏内科,江苏南京210002 |
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| 摘 要： | 目的：结合冠状动脉狭窄程度，探讨冠心病患者血清同型半胱氨酸（ Hcy）与微小RNA（ miR-1、miR-126及miR-208）之间的相互关系。方法选取行冠脉造影术的患者共102名，根据造影结果分为对照组和观察组，检测Hcy、miR-1、miR-126及miR-208水平，同时对冠脉造影结果进行评价并计算Gensini积分，应用相关及线性回归分析Hcy、miRNA（ miR-1、miR-126、miR-208）以及Gensini积分的相互关系。结果观察组血清Hcy、miRNA（miR-1、miR-126、miR-208）水平均高于对照组，血清Hcy、miR-1和miR-126水平分别与Gensini积分呈正相关相关系数（r）分别为0．575、0．649、0．499，P均＜0．01]，偏相关分析校正后它们之间仍然呈正相关（ r’分别为0．693、0．621、0．532，P均＜0．05）；而血清Hcy与miR-1、miR-126水平亦呈正相关（r分别为0．513、0．56，P均＜0．01），偏相关分析校正后排除年龄，体重指数，高血压和高脂血症病史的影响，其间仍然呈正相关（r’分别为0．599、0．614，P均＜0．05），而与miR-208无显著相关性。结论血清Hcy、miRNA（miR-1、miR-126、miR-208）均是评价冠心病的独立危险因素，其水平均随着冠脉病变严重程度的加重而增加。
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| 关 键 词： | 冠心病 同型半胱氨酸 微小核糖核酸-1 微小核糖核酸-126 微小核糖核酸-208 |
Correlation analysis of Hcy,miR-1,miR-126 and miR-208 in coronary heart disease patients |
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| Institution: | JIN Jie, WANG Jun, WANG Lei, CAI Xiao-min, WANG Li-jun, GONG Jian-bin ( 1. Department of Internal, Hangzhou Air Force Medical Appraisement Center, Zhejiang 310007, China ;2. Department of Cardiology, Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing , Jiangsu 210002, China) |
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| Abstract: | Objective To study the correlation between miRNA （miR-1,miR-126,miR-208） and homocysteine （Hcy） con-bining on the severity of stenosis of coronary artery .Methods One hundred and two patients undergoing quantitative coronary angiogra -phy were involved in this study .Patients were categorized into control group and coronary artery disease （ CAD） group.The concentra-tion of Hcy and miRNA （miR-1,miR-126,miR-208） were measured.The severity scale of coronary artery stenosis was quantitatively assessed according to coronary angiography by Gensini score .The correlation analysis and linear regression were used to show the asso-ciation of Hcy,miRNA （miR-1,miR-126 and miR-208） and Gensini score.Results The concentration of Hcy and miRNA （miR-1, miR-126 and miR-208） were higher in CAD group than those in control group .In the correlation analysis ,Gensini score was positively associated with Hcy,miR-1 and miR-126 （r=0.575,0.649,and 0.499,P〈0.01） and the positive correlation between them remained significant after revising partial correlation analysis （r＇=0.693,0.621,and 0.532,P〈0.05）.Hcy was influenced by miR-1 and miR-126 both in the Spearson correlation analysis （r=0.513,0.56,P〈0.01） and partial correlation analysis （r＇=0.599,0.614,P〈0.05）,but not by miR-208.Conclusion Hcy,miRNA （miR-1,miR-126 and miR-208） are independent risk factor for coronary heart disease and are increased along with stenosis of coronary arteries . |
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| Keywords: | coronary heart disease homocysteine miR-1 miR-126 miR-208 |
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