叉头框蛋白 M1、环氧合酶2在结肠癌组织中的表达及相关性分析

目的：探讨叉头框蛋白M1（fork head box M1，FoxM1）和环氧合酶2（cyclooxygenase2，COX-2）在结肠癌（colorec-tal carcinoma，CRC）中的表达及两者的相关性。方法采用免疫组织化学法检测FoxM1和COX-2在95例CRC组织和40例正常结肠组织中的表达，分析FoxM1和COX-2与结肠癌临床病理参数间的关系及两者表达的相关性。结果 FoxM1和COX-2在CRC组织中表达阳性率分别为85．3％（81／95）和87．4％（83／95），显著高于正常结肠组织的7．5％（3／40）和12.5％（5／40）（P＜0.05）。 FoxM1和COX-2的高表达与较多的淋巴结转移及较晚的临床分期密切相关（P＜0．05），且两者在CRC中的表达强度呈正相关（ r＝0．638，P＜0.05）。结论 FoxM1和COX-2的表达与CRC临床分期和淋巴结转移密切相关，提示其可能与CRC患者较差的预后相关。

Expression and correlation of FoxM1 and COX-2 in colorectal cancer

Objective To investigate the expression of fork head box M 1（FoxM1） and cyclooxygenase-2 （COX-2） in color-ectal cancer （CRC） and analyze the correlation between them .Methods Expressions of FoxM1and COX-2 were examined in 95 CRC tissues and 40 normal colon tissues by immunohistochemistry .Then the relationships among expression of FoxM 1and COX-2 and clinico-pathological parameters of CRC analyzed .Results Both the positivity rates of FoxM 1 and COX-2 in CRC tissues were significantly higher than in normal colon tissues FoxM1：85.3%（81/95 ）vs 7.5%（3/40）;COX-2：87.4%（83/95） vs 12.5%（5/40）;P〈0.05 ] .Enhanced expressions of FoxM 1 and COX-2 were still significantly correlated with the lymph node metastasis and advanced clin-ical stages in CRC （P〈0.05）.Meanwhile,a positive correlation was observed between FoxM 1 and COX-2 experssions （r=0.638,P〈0.05）.Conclusion Over-expressions of FoxM1 and COX-2 are significantly correlated with the lymph node metastasis and advanced clinical stage of CRC in the development and advancement of CRC .