Positron emission tomography for preoperative staging of colorectal carcinoma |
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Authors: | P. M. Falk M.D. N. C. Gupta M.D. Dr. A. G. Thorson M.D. M. P. Frick M.D. B. M. Boman M.D. Ph.D. M. A. Christensen M.D. G. J. Blatchford M.D. |
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Affiliation: | (1) Department of Surgery, Section of Colon and Rectal Surgery, Creighton University School of Medicine, 601 North 30th Street Suite 3520, 68131 Omaha, Nebraska;(2) Department of Radiology, Creighton University School of Medicine, Omaha, Nebraska;(3) Creighton Cancer Center, Creighton University School of Medicine, Omaha, Nebraska;(4) Department of Radiology, West Virginia University School of Medicine, Morgantown, West Virginia |
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Abstract: | PURPOSE: Positron emission tomography (PET) is an imaging technique based onin vivo cellular metabolism. Increased glucose metabolism in neoplastic cells is detected by using fluorine-18 deoxyglucose. In an ongoing pilot study to determine the usefulness of this technique, PET is compared with computerized tomography (CT) for the preoperative staging of colorectal carcinoma. METHODS: Sixteen patients were evaluated with both PET and CT of the abdomen and pelvis. Results were compared with operative and histopathologic findings. Fifteen malignant lesions were found in 16 patients by histology. PET had a positive predictive value of 93 percent and a negative predictive value of 50 percent. By comparison CT had a positive predictive value of 100 percent and a negative predictive value of 27 percent. CONCLUSIONS: These preliminary results indicate that PET has increased sensitivity for staging colorectal carcinoma, whereas CT has higher specificity. The predictive value of a positive PET compares favorably with CT. Furthermore, the predictive accuracy for detection of colorectal carcinoma is 83 percent for PET and 56 percent for CT.Poster presentation at the meeting of The American Society of Colon and Rectal Surgeons, San Francisco, California, June 7 to 12, 1992.Presented in part in the Nebraska Medical Journal, February 1993. |
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Keywords: | Positron emission tomography Colorectal carcinoma Staging |
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