High-dose-rate brachytherapy for previously irradiated patients with recurrent esophageal cancer |
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| Authors: | Nonoshita Takeshi Sasaki Tomonari Hirata Hideki Toh Yasushi Shioyama Yoshiyuki Nakamura Katsumasa Honda Hiroshi |
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| Institution: | (1) Department of Radiology, Kitakyusyu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-ku, Kitakyusyu 802-0077, Japan;(2) Department of Radiology, National Kyushu Cancer Center, Fukuoka, Japan;(3) Department of Surgery, National Kyushu Cancer Center, Fukuoka, Japan;(4) Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan |
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| Abstract: | Purpose Our objective was to assess the feasibility, efficacy, and complications of high-dose-rate (HDR) brachytherapy for patients
with recurrent esophageal cancer after external radiotherapy.
Materials and methods Six patients with recurrent esophageal cancer after external radiotherapy were treated with HDR brachytherapy (Ir-192 source)
from January 2003 to February 2004. The median age of the patients was 69 years. All patients had received external radiotherapy
(median dose 60 Gy) before HDR brachytherapy. All patients underwent HDR brachytherapy once a week with a dose of 4 or 5 Gy
per fraction in the esophageal mucosa (median total dose 20 Gy). The Kaplan-Meier method was used to calculate local control
rates.
Results The median overall survival period was 30.0 months. Local control was observed in five patients and residual tumor in one
patient. Persistent local control was observed in two patients. No patient died of esophageal cancer, and all patients survived.
We observed no severe late complications related to HDR brachytherapy.
Conclusion These data suggest that HDR brachytherapy is an effective and safe treatment for patients with recurrent esophageal cancer
after external radiotherapy. |
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| Keywords: | Esophageal cancer Local recurrence High-dose-rate brachytherapy External radiotherapy Salvage treatment |
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