抗凝、溶栓治疗下肢深静脉血栓对患者发生肺栓塞的影响

目的 探讨抗凝、溶栓治疗对下肢深静脉血栓(DVT)患者发生肺栓塞的影响.方法 回顾分析经抗凝、溶栓治疗并获随访的105例下肢深静脉血栓患者的临床资料,统计肺栓塞的发生率,并对患者的性别、年龄、血栓位置、血栓类型行单因素分析,探讨它们与肺栓塞发生的关系.结果 抗凝、溶栓治疗的患者住院期间有症状肺栓塞的发生率为2.86%(3/105),出院后随访无肺栓塞发生.肺栓塞的发牛率与性别、年龄、血栓位置、血栓类型无关(P=0.086,0.618,1.0,1.0).结论 对下肢DVT患者严格的抗凝、溶栓治疗可有效的降低其肺栓塞的发生率,故VCF的置入应严格掌握适应证.

The effects of anticoagulant and thrombolytic treatment of deep venous thrombosis on the prevalence of pulmonary embolism

Objective:To investigate the effects of anticoagulant and thrombolytic treatment of deep venous thrombosis (DVT) of lower limbs on the prevalence of pulmonary embolism (PE).
Methods:The clinical records of 105 patients with DVT treated with anticoagulation and thrombolysis were reviewed and analyzed.The incidence of PE, the related risk factors including sex, age, the location and type of thrombosis was analysis to explore the relationship between them and the occurrence of PE.
Results:The incidence of PE in patients treated with anticoagulation and thrombolysis alone during hospitalization was 2.86% (3/105), while no patients suffered from PE after discharge from hospital. The occurrence of PE had no relationship with sex, age, or locations and types of thrombosis (P=0.086, 0.618, 1.0，1.0 respectively).
Conclusions:Strict adherence to the guidelines of anticoagulant and thrombolytic therapy can effectively reduce the incidence of PE in patients with DTV of lowe limbs. Thus, the indications for inferior vena cava filter placement should be strictly grasped by clinicians.