Alteration of p53 Clonality Accompanying Colorectal Cancer Progression |
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| Authors: | Akifumi Kuwabara Hidenobu Watanabe Yoichi Ajioka Kazuhiro Yasuda Hidetoshi Saito Keiji Matsuda Hiroshi Kijima Katuyoshi Hatakeyama |
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| Affiliation: | First Department of Pathology, Niigata University School of Medicine, 1 Asahimachi-dori, Niigata 951;First Department of Surgery, Niigata University School of Medicine, 1 Asahimachi-dori, Niigata 951;First Department of Surgery, Tokyo University School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113;Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa 259-11 |
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| Abstract: | The aim of this study was to clarify whether or not the status of gene alteration is heterogeneous in intramucosal carcinoma and homogeneous within invasive carcinoma. We selected 10 colorectal carcinoma cases (1 mucosal, 5 submucosal and 4 advanced carcinomas including 2 cases with lymph node metastasis) and analyzed the p53 gene sequence. Six colorectal cancers in this study showed heterogeneity in p53 mutations in cells from the intramucosal part. In the invasive part of a carcinoma, p53 mutation status was homogeneous intratumorally in all cases. These data indicate that, in regard to p53 gene alterations, colorectal cancers can be composed of various subclones when limited to the mucosa, but clonal selection occurs when one of these subclones commences invasion to the submucosa, generating a monoclonal invasive carcinoma. |
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| Keywords: | Colorectal cancer p53 gene Clonality Heterogeneity Intramucosal carcinoma |
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