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| 2型糖尿病患者血清MMP-9、CRP与下肢血管病变的关系 | |
| 引用本文： | 谭擎缨,李红,王静,成军.2型糖尿病患者血清MMP-9、CRP与下肢血管病变的关系[J].中华内分泌代谢杂志,2009,25(1). |
| 作者姓名： | 谭擎缨 李红 王静 成军 |
| 作者单位： | 1. 解放军第117医院内分泌科,杭州,310013 2. 浙江大学医学院附属邵逸夫医院内分泌科 3. 解放军第117医院,检验科,杭州,310013 |
| 摘 要： | 对2型糖尿病患者行下肢血管B超检查,并比较血清基质金属蛋白酶9(MMP-9)及高敏C反应蛋白(hsCRP)水平问的关系.单纯2型糖尿病及经B超提示伴下肢血管病变患者均有不同程度的MMP-9及hsCRP升高,病变程度与hsCRP、MMP-9呈正相关,血清MMP-9水平与hsCRP呈正相关. |
| 关 键 词： | 基质金属蛋白酶9 C反应蛋白质 糖尿病 2型 大血管病变 |
Association of serum matrix metalloproteinase-9 levels and C-reactive protein with peripheral vascular disease of lower limbs in type 2 diabetes mellitus |
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| TAN Qing-ying,LI Hong,WANG Jing,CHENG Jun.Association of serum matrix metalloproteinase-9 levels and C-reactive protein with peripheral vascular disease of lower limbs in type 2 diabetes mellitus[J].Chinese Journal of Endocrinology and Metabolism,2009,25(1). | |
| Authors: | TAN Qing-ying LI Hong WANG Jing CHENG Jun |
| Abstract: | Serum matrix metalloproteinase-9 (MMP-9), hypersensitive C-reactive protein (hsCRP) and other clinical parameters were measured in patients with types 2 diabetes mellitu (with or without angiopathy of lower limbs). The serum levels of MMP-9 and hsCRP were higher in type 2 diabetic patients and those with angiopathy by Doppler ultrasonography than those in normal controls. The change of serum MMP-9 was positively correlated with the level of hsCRP. The extent of angiopathy was correlated positively with both hsCRP and MMP-9. |
| Keywords: | Matrix metalloproteinase-9 C-reactive protein Diabetes mellitus type 2 Angiopathy |
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