Postmortem MRI changes of the brains of the rats of different ages |
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Authors: | Xu Jie Zou Yan Zhang Li-Hong Wai Maria Sen Mun Kung Hsiang-Fu Ge Zhen-Ying Yew David T |
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Affiliation: | Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China. |
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Abstract: | Brain degenerative changes were studied in the rats of different ages after cervical dislocation by T(2) MRI and histology. Appearance of dark spots in the T(2) images increased with increased duration after death. Quantitative analysis of the density of these spots revealed that the neonatal (1 week) and the old (9 months) animals had accelerated degenerative changes when compared with the young adult (1 month). The degenerative changes correlated with the accumulation of vacuoles or spaces in the brain tissue histologically. This study pointed out not only brain degenerative changes after death were associated with age, it also revealed that the MRI T(2) evaluations could be used as a way in postmortem investigation. |
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