合并应用氯丙嗪对青霉素在感染金黄色葡萄球菌小鼠疗效的影响

抗菌素和氯丙嗪在临床上常常合并应用,有文报导氯丙嗪有加剧实验性感染的作用.本实验室曾发现氯丙嗪在试管内有增强青霉素对耐青霉素金黄色葡萄球菌的抑制作用.为了探讨这个问题,本文以这个菌株制成5％粘液素菌悬液腹腔感染小鼠,在不同时间由背部皮下给青霉素及腹部皮下给氯丙嗪进行治疗,观察合并用药的效果.实验结果说明,当每鼠感染10(~-4)菌液0.5毫升(约2×10~4个活菌)后,给不同量的氯丙嗪,明显地看出5毫克/公斤的氯丙嗪有加剧感染的作用,小鼠4天内生存率为6.7％,而不给氯丙嗪的对照组为53.3％;感染量减低10倍时,给氯丙嗪组为40％,对照组为86.7 ％.

THE EFFECTS OF CHLORPROMAZINE ON PENICILLIN THERAPY OF STAPHYLOCOCCAL INFECTION IN MICE

It has been confirmed by the present experiments that chlorpromazine reduced the survival rate of mice infected intraperitonelly with penicillin-resistant Staph. aureus. The therapeutic efficacy of penicillin in the infected mice was also reduced by chlorpromazine. The time of injection of each drug seemed to be also an influencing factor to the reduc- tion of therapeutic efficacy.