二氧化硫对小鼠胃组织氧化损伤的作用

目的　了解二氧化硫 (SO2 )对哺乳动物胃组织的毒理作用及其机制。方法　采用SO2 动态吸入SO2 技术 ,使昆明小鼠吸入SO2 ,浓度为 (2 2± 2 ) ,(6 4± 3) ,(1 4 8± 2 3)mg/m3 ,每天 6h ,连续 7d ,分析该小鼠胃组织氧化损伤及抗氧化状态。结果　在SO2 浓度为 2 2mg/m3 时 ,雄鼠胃组织的超氧化物歧化酶(SOD)、过氧化氢酶 (CAT)活力及雌鼠胃组织的脂质过氧化 (LPO)水平显著升高 ;在SO2 浓度为 6 4mg/m3和 1 4 8mg/m3 时 ,雌、雄鼠胃组织的LPO水平显著升高 ,SOD酶活力和还原型谷胱甘肽 (GSH)含量显著下降。结论　吸入SO2 可引起小鼠胃组织多种抗氧化指标发生显著变化 ,表明SO2 对小鼠胃组织产生了氧化损伤作用 ;SO2 的毒理作用与其诱发产生过量自由基有关

Effects of Oxidation Damage on Stomach Tissues of Mice by Sulfur Dioxide

Objective To study the toxicological effect and its mechanism of SO 2 on mammals and their stomachs.Methods Kunming mice were exposed to SO 2 by dynamic inhalation at different concentrations.Oxidation damage on stomach tissues and anti oxidation state were observed.Results When the concentration of SO 2 was 22 mg/m 3 ,activities of SOD and CAT in male mice stomach tissues and levels of LPO in female ones increased significantly.Moreover,at 64 mg/m 3 and 148 mg/m 3 of SO 2,LPO in both male and female mice stomach tissues increased significantly,while SOD activities and GSH levels decreased significantly.Conclusions SO 2 inhalation can lead to significant changes of anti oxidation indices in mice stomach tissues.Its toxicological effect is associated with excessive induction of free radicals in vivo.