Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells |
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Authors: | Chen Shu-Ching Huang Chiu-Chen Chien Chung-Liang Jeng Chung-Jiuan Su Ho-Ting Chiang Evelyn Liu Meng-Ru Wu C H Herbert Chang Chung-Nan Lin Rong-Hwa |
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Affiliation: | Graduate Institute of Immunology and Department of Anatomy and Cell Biology, Colege of Medicine, National Taiwan University, Taipei, Taiwan. |
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Abstract: | Increasing evidence has shown that death signaling in T cells is regulated in a complicated way. Molecules other than death receptors can also trigger T-cell death. Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells. In contrast to classic cell death, PSGL-1-mediated T-cell death is caspase independent. It involves translocation of apoptosis-inducing factor from mitochondria to nucleus and mitochondrial cytochrome c release. Ultrastructurally, both peripheral condensation of chromatin and apoptotic body were observed in PSGL-1-mediated T-cell death. Collectively, this study demonstrates a novel role for PSGL-1 in controlling activated T-cell death and, thus, advances our understanding of immune regulation. |
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