短暂脑缺血发作特点与脑梗死的关系研究

目的:探讨短暂脑缺血发作(TIA)发作持续时间、发作次数及临床特征与脑梗死的关系。方法:对173例TIA患者临床资料进行回顾性分析,记录其发作持续时间、发作次数及临床特征。发作后均在24小时内行头颅MRI或CT检查,部分于发作48小时后复查,记录影像学异常(责任病灶)的例数。结果:TIA发作≤30分钟、>30分钟患者发生脑梗死比例分别为16/112、22/61,组间比较差异具有显著意义(P<0.01);TIA发作≤3次、>3次TIA患者发生脑梗死比例分别为19/129、19/44,组间比较差异具有显著意义(P<0.01);既往有、无卒中病史者发生脑梗死比例分别为15/43、23/130,组间比较差异具有显著意义(P<0.05);既往有、无高血压病史者发生脑梗死比例为28/102、10/71,组间比较差异具有显著意义(P<0.05);表现为偏肢无力和(或)麻木、非偏肢无力麻木者发生脑梗死的比例分别为33/82、5/91,组间比较差异具有显著意义(P<0.01)。结论:局灶神经功能障碍持续时间>30分钟、发作次数>3次、既往有卒中、高血压病史及表现为偏肢无力和(或)麻木的TIA患者发生脑梗死的比率明显增高。

The relationship between attack charactors of transient ischemia attack and cerebral infarction

Objective: To study the relationship between duration,attack times,clinical charactors of transient ischemia attack(TIA) and cerebral infarction. Methods: 173 patients of TIA were studied about the duration, attack times and the clinical charactors.All of the patients were examined by MRI or CT,and some of them were repeated after 48h, study the imaging abnormalities that responsible to the cases. Results: In cases that TIA persisting for less than 30 min and more than 30 min,the brain infarction rates were 16/112 and 22/61, there were significant difference between the two groups(P<0.01); TIA that the attack was less than 3 times and more than 3 times, the brain infarction rates were19/129 and 19/44, there were significant difference between the two groups(P<0.01). Conclusion: There was a high incidence of cerebral infarction in patients with TIA that the attack lasted over 30 min or the attack was over 3 times.