甲状腺功能性减退症与不孕症相关性研究进展

近年来,女性不孕症的患病率逐年升高,研究表明其与性腺轴及性激素的调节作用有关。而甲状腺疾病一直以来都备受关注,它是育龄期女性第二常见的内分泌疾病,其中甲状腺功能减退及相关的甲状腺功能异常在临床中最为常见。随着对这两种疾病及激素研究程度的不断深入,加深了对两者间相关性认识。当甲状腺调节轴及相关激素水平发生变化后,随之影响性腺轴的调节以及卵巢功能,导致性激素水平在一定程度上相应地发生改变。可见,甲状腺激素、性激素、甲状腺轴以及性腺轴之间的相互关系在正常妊娠过程起着至关重要的作用。对甲状腺功能减退及相关的甲状腺功能异常与不孕症之间的相关性的研究进展进行综述。

Advances on the study of the relationship between hypothyroidism and infertility

In recent years,the incidence of female infertility is increasing,studies have shown that it is closely related to the regulation of gonad axis and sex hormones.Thyroid disease has long been a concern,it is the second most common endocrine disorders in women of childbearing age,including hypothyroidism and thyroid dysfunction related which is the most common in clinical.With the deepening of the study of these two diseases and related hormones,the correlation between the two is deepened.When the thyroid gland axis and related hormone levels changed,the gonad axis and the regulation of ovarian function are going to be affected,causing a corresponding change of the sex hormone levels to a certain extent.Consequently,the relationship between thyroid hormone,sex hormone,thyroid axis and gonad axis plays an important role in normal pregnancy process.The progresses of researches about the correlation between hypothyroidism and thyroid dysfunction related and infertility are summarized.