耳穴贴压联合阿托伐他汀治疗非酒精性脂肪肝40例临床观察

目的观察耳穴贴压联合阿托伐他汀治疗非酒精性脂肪肝的临床疗效。方法将80例非酒精性脂肪肝患者随机分为2组。对照组40例予阿托伐他汀片治疗,治疗组40例在对照组治疗基础上加用耳穴贴压治疗。2组均治疗2个月后统计临床疗效,并观察2组治疗前后肝功能丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)及γ-谷氨酰转移酶(γ-GT)]及甘油三酯(TG)、总胆固醇(TC)、胰岛素抵抗指数变化。结果治疗组有效率95.00%,对照组有效率80.00%,2组比较差异有统计学意义(P0.05),治疗组疗效优于对照组。2组治疗后ALT、AST、γ-GT、TG、TC及胰岛素抵抗指数均降低(P0.05),且治疗组降低优于对照组(P0.05)。结论耳穴贴压联合阿托伐他汀治疗非酒精性脂肪肝疗效确切,且能改善肝功能,降低TG、TC及胰岛素抵抗指数。

Clinical observation of auricular-plaster therapy combined with atorvastatin on the treatment of nonalcoholic fatty liver disease

Objective To observe the clinical effects of auricular-plaster therapy combined with atorvastatin on the treatment of nonalcoholic fatty liver disease (NAFLD).Methods 80 NAFLD patients were randomly divided into two groups.40 patients in control group were treated by atorvastatin.40 patients in treatment group were treated by auricular-plaster therapy on the basis of control group treatment.The curative effect was evaluated two months after treatment in two groups.The liver function,including alanine aminotransferase (ALT),aspartate aminotransferase (AST) and γ-glutamyl transpeptidase (γ-GT) before and after treatment were observed in two grouops,as well as the changes of triglyceride (TG),total cholesterol (TC) and insulin resistance index (IRI).Results The effective rate in treatment group (95.00％) was superior to that in control group (80.00％,P ＜ 0.05).The ALT,AST,γ-GT,TG,TC and IRI after treatment were decreased in two groups (P ＜ 0.05),and the decrease in treatment group was superior to that in control group (P ＜ 0.05).Conclusion Auricular-plaster therapy combined with atorvastatin have exact effect on the treatment of NAFLD,can improve liver function,decrease the levels of TG,TC and IRI.