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Curcuma sp.‐derived dehydrocurdione induces heme oxygenase‐1 through a Michael reaction between its α, β‐unsaturated carbonyl and Keap1 |
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| Authors: | Masatoshi Ohnishi Tomoka Urasaki Kyohei Egusa Chihiro Kunobu Tomoki Harada Reika Shinkado Hitomi Nishi Shoji Maehara Chinami Kitamura Toshiyuki Hata Kazuyoshi Ohashi Hirotaka Shibuya Atsuko Inoue |
| Institution: | 1. Department of Pharmacotherapeutics, Graduate School of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan;2. Department of Pharmacotherapeutics, Fukuyama University, Fukuyama, Hiroshima, Japan;3. Department of Physical Chemistry for Bioactive Molecules, Fukuyama University, Fukuyama, Hiroshima, Japan;4. Department of Natural Product Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima, Japan |
| Abstract: | |
| Keywords: | dehydrocurdione HO‐1 HO‐1 E2 enhancer Keap1 Nrf2 |