三维连通多孔钛修饰的人工股骨复合骨形态发生蛋白的实验研究

目的将人工股骨柄表面贴敷复合了骨形态发生蛋白的三维连通多孔钛,观察早期骨长入情况。方法将表面贴敷三维连通多孔钛的犬人工股骨柄直接或通过纤维蛋白胶与骨形态发生蛋白复合,植入犬股骨,植入后2、5周荧光标记,3、6周取材病理观察。结果植入后3周,骨已长入多孔材料一半,植入后6周,宿主骨与假体成为一体,骨长入多孔材料全层;第6周时成骨量明显高于第3周。结论具有三维连通多孔钛表面的假体与骨形态发生蛋白复合后能使骨长入加快,骨整合的程度提高,达到机械锁定和骨整合的双重固定,减少假体松动。

Experimental study of prostheses modified by three dimensions porous Ti combined bone morphogenetic proteins

OBJECTIVE: To observe bone ingrowth of artificial femur which three dimensions (3-D) porous Ti combined bone morphogenetic proteins (BMPs) integrating on the prothesis surface in dogs. METHODS: The protheses integrated 3-D porous Ti on the surface, which combined BMPs directly or through FG, were implanted canine. And fluorescent labeling was done at 2, 5 weeks after that, and then the protheses with femurs were taken out in 3, 6 weeks after operation. These specimens were treated, then observed through microscopy. RESULTS: At 3 weeks, bone growing 1/2 of full thickness in 3-D porous Ti, but bone growing full thickness in 3-D porous Ti at 6 weeks. Bone formation was obviously higher at 6 weeks than at 3 weeks. CONCLUSION: The protheses modified 3-D porous Ti can accelerate osteogenesis and improve bone formation so that mechanical interlock and integration can be come true.