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载脂蛋白与冠状动脉病变严重度的相关研究
引用本文:潘其兴,王树春,潘景韬,刘芃,季晓平,吴湘云,胡晓燕,王明运,孙秉莹,陈淑芹. 载脂蛋白与冠状动脉病变严重度的相关研究[J]. 中国心脏起搏与心电生理杂志, 1991, 0(2)
作者姓名:潘其兴  王树春  潘景韬  刘芃  季晓平  吴湘云  胡晓燕  王明运  孙秉莹  陈淑芹
作者单位:山东医科大学附属医院心内科,山东医科大学附属医院心内科,山东医科大学附属医院心内科,山东医科大学附属医院心内科,山东医科大学附属医院心内科,山东医科大学生物化学教研室,山东医科大学生物化学教研室,山东医科大学生物化学教研室,山东医科大学附属医院检验科,山东医科大学附属医院检验科
摘    要:对40例病人进行选择性冠状动脉造影,同时测定血浆载脂蛋白A-1(ApoA-Ⅰ)及B(ApoB)的水平,研究Apo与冠状动脉病变(CAD)严重度之间的关系。并测定血清总胆固醇、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及极低密度脂蛋白胆固醇的含量,用以对比分析。结果表明:ApoA-Ⅰ水平下降是临床上诊断CAD的较佳指标;ApoB/ApoA-Ⅰ比值增大对判断CAD严重度较可靠;ApoB/ApoA-Ⅰ=0.98~1.00作为有无发生早期CAD的一个“临界值”有一定参考价值。

关 键 词:载脂蛋白  冠心病  冠状动脉造影

Study on Serum Apoprotein Levels as Indicators of The Severity of Angiographically Assessed Coronary Artery Disease
Pan Qixing,. Study on Serum Apoprotein Levels as Indicators of The Severity of Angiographically Assessed Coronary Artery Disease[J]. Chinese Journal of Cardiac Pacing and Electrophysiology, 1991, 0(2)
Authors:Pan Qixing  
Abstract:To study the relationship between the apoproteins and the severity of Coronary artery disease, serum apoproteins (Apo) A-I and B were determined in 40 subjects undergoing coronary angiography because of old myocardial infaction and angina pectoris. In the meantime, serum total cholesterol, triglyceride, HDL-, LDL-, and VLDL-cholesterol concentration were determined for control analysis. The results showed that the decrease of serum ApoA-I levies was the best indicator to distiguish coronary artery disease from non-coronary artery disease; ApoB/ApoA-I ratio had the most consistent association with the severity of coronary artery disease as assessed by angiography; ApoB/ApoA-I=0.98~1.00 may be considered as a critical value for early coronary artery disease.
Keywords:Apoprotein  Conronary artery disease  Coronary angiography
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