碘普罗胺的合成 |
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引用本文: | 王哲,陈仕洪,张婷婷,徐静静.碘普罗胺的合成[J].中国医药工业杂志,2012(7):527-529. |
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作者姓名: | 王哲 陈仕洪 张婷婷 徐静静 |
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作者单位: | 浙江司太立制药股份有限公司,浙江仙居,317300 |
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摘 要: | 3-氨基-5-(2,3-二乙酰氧基正丙胺基甲酰基)-2,4,6-三碘苯甲酸(6)经与甲氧基乙酰氯反应、碳酸氢钠作用下水解后再经氯代得3-(2-甲氧基)乙酰胺基]-5-(2,3-二羟基正丙胺基甲酰基)-2,4,6-三碘苯甲酰氯(4),4与N-甲基-2,3-二羟基丙胺反应制得碘普罗胺,总收率为80%(以6计)。
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关 键 词: | 碘普罗胺 造影剂 合成 |
Synthesis of Iopromide |
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Authors: | WANG Zhe CHEN Shihong ZHANG Tingting XU Jingjing |
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Institution: | (Zhejiang Starry Pharmaceutical Co.,Ltd.,Xianju 317300) |
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Abstract: | lopromide was synthesized from 3-amino-5-(2,3-diacetoxypropylcarbamoyl)-2,4,6- triiodobenzoic acid(6) by reaction with methoxyacetyl chloride,hydrolysis with NaHCO3 and chlorination to give 3- (2-methoxyacetylamino)-5-(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodobenzoyl chloride(4),followed by reaction with N-methyl-2,3-dihydroxypropylamine with an overall yield of about 80%(based on 6). |
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Keywords: | iopromide contrast agent synthesis |
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