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| 尖尾芋根茎石油醚部位抗肿瘤活性及化学成分研究 | |
| 引用本文： | 雷霄,冯怡,梁爽,王源,郑向炜. 尖尾芋根茎石油醚部位抗肿瘤活性及化学成分研究[J]. 中国医药工业杂志, 2012, 43(5): 340-343,380 |
| 作者姓名： | 雷霄 冯怡 梁爽 王源 郑向炜 |
| 作者单位： | 1. 上海中医药大学中药学院,上海,201203 2. 上海中医药大学中药学院,上海201203;中药现代制剂技术教育部工程研究中心,上海201203 3. 中药现代制剂技术教育部工程研究中心,上海,201203 |
| 摘 要： | 考察了尖尾芋根茎的不同溶剂提取物对5种人肿瘤细胞(M-GC803、Hela、bel7402、K-562和MDA-MB-435)的抑制作用。结果表明,尖尾芋根茎50%乙醇提取物的抑制作用较强,进一步筛选显示该提取物的石油醚萃取部位对人肿瘤细胞M-GC803的抑制活性较显著(IC50=121 g/ml)。采用GC-MS法分析该石油醚部位的化学成分,共鉴定了其中43个化学成分,含量占前5位的成分分别是:亚油酸(23.59%)、十六烷酸(18.91%)、间十五烷基酚(15.51%)、亚麻酸(9.09%)和3’-甲氧基苯并[1’,2’-b]-1,4-二氮杂双环[2.2.2]辛烯(5.18%)。 |
| 关 键 词： | 尖尾芋 乙醇提取物 石油醚部位 抗肿瘤活性 化学成分 |
Antitumor Effect and Chemical Constitutes of the Petroleum ether Fraction from the Rhizome of Alocasia cucullatta (Lour.) Schott |
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| LEI Xiao , FENG Yi , LIANG Shuang , WANG Yuan , ZHENG Xiangwei. Antitumor Effect and Chemical Constitutes of the Petroleum ether Fraction from the Rhizome of Alocasia cucullatta (Lour.) Schott[J]. , 2012, 43(5): 340-343,380 | |
| Authors: | LEI Xiao FENG Yi LIANG Shuang WANG Yuan ZHENG Xiangwei |
| Affiliation: | 1.College of Traditional Chinese Medicine,Shanghai University of TCM,Shanghai 201203; 2.Engineering Research Center of Modern Preparation Technology of TCM,Ministry of Education,Shanghai 201203) |
| Abstract: | The inhibition effects of the extracts of the rhizome of Alocasia cucullata(Lour.) Schott with different solvents on five human tumor cells(M-GC803,Hela,bel7402,K-562 and MDA-MB-435) were investigated.The results showed that the 50% ethanol extract had a stronger inhibition effect.The further study showed that the petroleum ether fraction from 50% ethanol extract had a significant inhibition effect on M-GC803 cells(IC50=121 μg/ml).Among the forty three ingredients whose content accounted for the top five were as follows:(Z,Z)-9,12-octadecadienoic acid(23.59%), hexadecanoic acid(18.91%),3-pentadecylphenol(15.51%),(Z,Z,Z)-9,12,15-octadecatrienoic acid(9.09%) and 3’-methoxybenzo[1’,2’-b]-1,4-diazabicyclooctene(5.18%). |
| Keywords: | Alocasia cucullata(Lour.) Schott ethanol extract petroleum ether fraction antitumor effect chemical constituent |
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