| 奈韦拉平的合成 |
| |
| 引用本文： | 竺伟,陈欢生,胡永安. 奈韦拉平的合成[J]. 中国医药工业杂志, 2012, 43(6): 411-413 |
| |
| 作者姓名： | 竺伟 陈欢生 胡永安 |
| |
| 作者单位： | 上海奥博生物医药技术有限公司,上海,201203 |
| |
| 摘 要： | 2-氯-N-(2-氯-4-甲基-3-吡啶基)烟酰胺与环丙胺于室温在氯化亚铜催化下偶联,所得N-(2-氯-4-甲基-3-吡啶基)-2-环丙胺基烟酰胺在碱性条件下闭环即可得到抗病毒药奈韦拉平,总收率达82%。
|
| 关 键 词： | 奈韦拉平 抗感染药 合成 |
Synthesis of Nevirapine |
| |
| ZHU Wei , CHEN Huansheng , HU Yongan. Synthesis of Nevirapine[J]. Chinese Journal of Pharmaceuticals, 2012, 43(6): 411-413 |
| |
| Authors: | ZHU Wei CHEN Huansheng HU Yongan |
| |
| Affiliation: | (Shanghai AoBo Bio-pharmaceutical Technology Co.,Ltd.,Shanghai 201203) |
| |
| Abstract: | 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)-nicotinamide was coupled with cyclopropyl amine with CuCl as catalyst at room temperature,the obtained N-(2-chloro-4-methylpyridin-3-yl)-2-cyclopropylaminonicotinamide was cyclized under basic condition to obtain anti-infective agent nevirapine,the total yield was about 82%. |
| |
| Keywords: | nevirapine anti-infective agent synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
