| 利妥昔单抗治疗儿童原发性肾病综合征研究进展 |
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| 引用本文： | 孟磊,任榕娜,余自华. 利妥昔单抗治疗儿童原发性肾病综合征研究进展[J]. 实用儿科临床杂志, 2011, 26(5): 375-378 |
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| 作者姓名： | 孟磊 任榕娜 余自华 |
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| 作者单位： | 福建医科大学福州总医院临床医学院,儿科,福州,350025;南京军区福州总医院,儿科,福州,350025 |
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| 基金项目： | 福建省自然科学基金(2006J0119); 南京军区医学科学技术研究“十一·五”计划课题(06MA148,06MA151);南京军区医学科技创新课题(08MA102) |
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| 摘 要： | 原发性肾病综合征(PNS)是儿童时期常见的肾小球疾病,约25%的频复发型肾病综合征(FRNS)或激素依赖型肾病综合征(SDNS)患儿在成年期仍需用激素和(或)免疫抑制剂(ISA)维持治疗;约35%的激素耐药型肾病综合征(SRNS)患儿加用免疫抑制剂仍不缓解.利妥昔单抗是一种人鼠嵌合型抗CD20单克隆抗体,作为PNS的三线药物用于治疗对ISA如环磷酰胺、环孢素、他克莫司、霉酚酸酯等反应不佳、且不良反应严重的FRNS/SDNS和SRNS患儿,已取得较好的近期疗效,其远期疗效及安全性尚需多中心、前瞻性、大样本的随机对照试验证实.
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| 关 键 词： | 肾病综合征 利妥昔单抗 儿童 |
Study Progress of Rituximab Therapy on Primary Nephrotic Syndrome in Children |
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| MENG Lei , REN Rong-na , YU Zi-hua. Study Progress of Rituximab Therapy on Primary Nephrotic Syndrome in Children[J]. Journal of Applied Clinical Pediatrics, 2011, 26(5): 375-378 |
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| Authors: | MENG Lei REN Rong-na YU Zi-hua |
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| Affiliation: | MENG Lei~1,2,REN Rong-na~1,YU Zi-hua~1,2(1.Department of Pediatrics,Fuzhou Clinical Medical College,Fuzhou General Hospital,Fujian Medical University,Fuzhou 350025,Fujian Province,China,2.Department of Pediatrics,Fuzhou General Hospital of Nanjing Command,China) |
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| Abstract: | Primary nephrotic syndrome(PNS) is the common glomerular disease during childhood,about 25% of children with frequently relapsing nephrotic syndrome(FRNS) or steroid-dependent nephrotic syndrome(SDNS) still need prolonged treatment with steroids/immunosuppressive agents(ISA) in adulthood,and about 35% of children with steroid-resistant nephrotic syndrome(SRNS) treated with additio-nal ISA have achieved no remission.Rituximab,a chimeric human/mouse monoclonal anti-CD_20 antibody,is a third-line drug for trea... |
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| Keywords: | nephrotic syndrome rituximab child |
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