布地奈德福莫特罗粉吸入剂对中度支气管哮喘患儿小呼吸道功能的影响

目的 观察布地奈德福莫特罗粉吸入剂治疗儿童中度支气管哮喘的疗效和不良反应及对小呼吸道功能的影响.方法 选取青岛大学医学院附属医院哮喘专家门诊初诊的中度支气管哮喘患儿40例,病例均未接受过正规吸入激素治疗.入院后给予布地奈德福莫特罗粉吸入剂,每次1吸,每天2次,治疗12周.分别在治疗4周、8周、12周进行哮喘控制水平(控制、部分控制、未控制)评估,同时测定其肺功能,包括一秒钟用力呼气量(FEV1)占预计值百分比、最大呼气流量(PEF)占预计值百分比、25%用力呼气肺活量(FEF25)、50%用力呼气肺活量(FEF50)、75%用力呼气肺活量(FEF75),并观察不良反应发生情况.对治疗前后肺功能结果 进行比较,同时进行病情评估.结果 1.临床控制率:治疗12周,临床控制36例(90%),部分控制4例(10%),总有效率为100%.2.肺功能改善情况:在治疗4周,FEV1、PEF、FEF25、FEF50、FEF75均有显著改善,且在12周的随访过程中,上述指标得到持续改善.治疗12周FEF75、FEF50、FEF25均恢复到正常水平.结论 布地奈德福莫特罗粉吸入剂治疗儿童中度支气管哮喘,对缓解症状和改善肺功能均有良好效果,尤其可有效改善哮喘患儿小呼吸道功能,从而达到哮喘临床控制或部分控制,且不良反应发生率低.

Effect of Budesonide Formoterol Fumarate Powder for Inhalation on Small Airway Function in Children with Moderate Asthma

Objective To observe the clinical efficacy and adverse reactions of budesonide formoterol fumarate powder for inhalation treatment in children with moderate asthma,and its effect on small airway function.Methods Forty children with moderate asthma were selected,who were doctored for the first time in asthma clinic of the Affiliated Hospital of Qingdao University Medical College.All the cases had not received formal inhaled corticosteroid before treatment,and were given budesonide formoterol fumarate powder ...