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| 肺泡表面活性物质蛋白B基因多态性与支气管肺发育不良易感性的关系 | |
| 引用本文： | 曾凌空,李文斌,潘睿,单瑞艳,刘汉楚,周玉荣,张佳,常立文.肺泡表面活性物质蛋白B基因多态性与支气管肺发育不良易感性的关系[J].实用儿科临床杂志,2011,26(2):132-134. |
| 作者姓名： | 曾凌空 李文斌 潘睿 单瑞艳 刘汉楚 周玉荣 张佳 常立文 |
| 作者单位： | 1. 华中科技大学同济医学院附属同济医院,儿科,武汉,430030;武汉市儿童医院,新生儿科,武汉,430016 2. 华中科技大学同济医学院附属同济医院,儿科,武汉,430030 3. 武汉市儿童医院,新生儿科,武汉,430016 |
| 基金项目： | 国家自然科学基金(30872795) |
| 摘 要： | 目的 了解肺泡表面活性物质蛋白B(SPB)-18A/C和SPB 1580C/T基因多态性与支气管肺发育不良(BPD)易感性的关系.方法 应用聚合酶链反应-限制性片段长度多态分析技术及基因测序技术检测57例BPD患儿及103例同胎龄无BPD早产儿的SPB-18及SPB 1580基因多态性,比较2组SPB-18及SPB 1580基因型和基因分布的差异.结果 1.SPB-18A/C基因型在BPD组与对照组AA、AC、CC基因型频率分别为14.0%、45.6%、40.4%和4.9%、31.1%、64.1%;A等位基因增加新生儿患BPD的风险:AC/CC与AA/CC 的OR值分别为2.3(95%CI 1.2~4.7,P=0.02)和4.7(95%CI 1.4~16.2,P=0.01);2.SPB 1580C/T基因型在对照组和BPD组TT、CT、TT分布分别为6.8%、45.6%、47.6%和12.3%、40.4%、47.4%,对照组和BPD组比较差异无统计学意义(χ2=1.50, P＞0.05).结论 中国武汉汉族人中SPB-18基因多态性是BPD的危险因素,基因型为AA者是BPD易感人群.SPB 1580 C/T基因多态性与BPD发病无明显相关性. |
| 关 键 词： | 肺泡表面活性物质蛋白 基因多态性 支气管肺发育不良 易感性 |
Relationship between Polymorphism of Surfactant Protein B Gene and Bronchopulmonary Dysplasia |
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| ZENG Ling-kong , LI Wen-bin , PAN Rui , SHAN Rui-yan , LIU Han-chu , ZHOU Yu-rong , ZHANG Jia , CHANG Li-wen.Relationship between Polymorphism of Surfactant Protein B Gene and Bronchopulmonary Dysplasia[J].Journal of Applied Clinical Pediatrics,2011,26(2):132-134. | |
| Authors: | ZENG Ling-kong LI Wen-bin PAN Rui SHAN Rui-yan LIU Han-chu ZHOU Yu-rong ZHANG Jia CHANG Li-wen |
| Institution: | ZENG Ling-kong1,2,LI Wen-bin1,PAN Rui1,SHAN Rui-yan1,LIU Han-chu2,ZHOU Yu-rong1,ZHANG Jia1,CHANG Li-wen1(1.Department of Pediatrics,Tongji Hospital Affiliated Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China,2.Department of Neonatology,Wuhan Children's Hospital,Wuhan 430016,China) |
| Abstract: | Objective To study the relationship between polymorphism of surfactant protein B(SPB)and susceptibility of bronchopulmonary dysplasia(BPD).Methods The genetic polymorphism of SPB gene-18A/C and SPB 1580C/T,coded for SPB,were analyzed and then compared by using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and gene sequencing in 57 children with BPD,and 103 children born at the same gestational without BPD.Results 1.The SPB-18 AA,AC,and CC genotype frequencies in BPD patients an... |
| Keywords: | surfactant protein B polymorphism bronchopulmonary dysplasia susceptibility |
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