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DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. |
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| Authors: | T Deguchi M Yasuda M Asano K Tada H Iwata H Komeda T Ezaki I Saito Y Kawada |
| Abstract: | Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli. |
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