肝素钙与肾小球内基质金属蛋白酶表达的关系探讨

目的 探讨肝素钙在治疗增生性肾炎中的作用。方法 对70例增生性肾小球肾炎患者，进行常规病理检查，并以免疫组化方法测定其肾小球基质金属蛋白酶（MMPs)-MMP-2、MMP－3的表达。同时随机分为常规疗法（A组）和常规疗法＋肝素钙（B组）两组。结果 A组和B组系膜增生程度、球性硬化、节段性硬化、MMP－2、MMP－3表达无显著性差异。B组和10例血肌酐增高者治疗前后血肌酐和内生肌酐清除率有显著性差异。B组的疗效优于A组。结论 加用肝素钙治疗慢性肾炎有理论上和实践上的意义。

Relation Between Hepacarin and the Expression of MMPs in Renal Glomerulus

Objective To explore the therapeutic effects of hepacarin on proliferative nephritis Methods: 70 patients of proliferative nephritis were randomly divided into 2 groups:group A (receiving routine treatment)and group B(receiving hepacarin and routine treatment) All patients received renal biopsy The expressions of MMP 2 MMP 3 of renal glomerulus were determined by immunohistochemical method Results:There were no significant differences in the degree of mesangial proliferation and segmented sclerosis between two group.No different expressions of MMP 2 and MMP 3 were observed between A and B group The serum levels of creatinine of 10 patients in group B were higher than normal There were markedly different in Scr and Ccr between pre and post treatment of group B.The therapeutic effect of group B was superior to group A Conclusions: The therapeatic effect of hepacarin on the chronic nephritis was significant