血清C-反应蛋白、白细胞介素-6水平与老年冠心病患者焦虑情绪的关系

目的:探讨血清炎性因子C-反应蛋白(CRP)、白细胞介素(IL-6)水平与老年冠心病患者伴焦虑情绪的相关性。方法:收集老年冠心病患者64例,进行焦虑自评量表(SAS)评分,根据评分结果将其分为冠心病不伴焦虑情绪组、冠心病伴焦虑情绪组,测定所有研究对象的血清CRP、IL-6水平。结果:64例患者中男性36例(56.25%),女性28例(43.75%),伴有焦虑情绪35例(47.45%),其中男性有15例(42.9%),女性20例(57.1%),男女冠心病患者伴焦虑情绪差异有统计学意义(P<0.05)。伴有焦虑情绪的血清CRP、IL-6水平与不伴有焦虑情绪的差异有统计学意义(P<0.05)。血清炎症因子水平CRP、IL-6与焦虑程度呈正相关。结论:伴有焦虑情绪的老年冠心病患者血清CRP、IL-6水平升高,且与焦虑程度呈正相关。

The relationship between anxiety and serum levels of c-reactive protein and interleukin-6 in the elderly patients with coronary heart disease

Objective:To investigate the relationship between anxiety and serum levels of inflammatory factors C-reactive protein(CRP) and interleukin-6(IL-6) in the elderly patients with coronary heart disease(CHD) Method:The self-rating anxiety scale(SAS) was applied to 64 patients with CHD.According to SAS score,64 patients were divided into two groups:elderly CHD patient with and without anxiety symptom group.The serum levels of inflammatory factors including C-reactive protein(CRP)、interleukin-6(IL-6) were tested.Results:All of subjects,male 36(56.25%) and female 28(43.75%),35(47.45%) patients showed anxiety including 15(42.9%)male and 20(57.1%) female patients.The sex difference was found in anxiety(P<0.05).The difference on CRP and IL-6 between with and without anxiety symptom group was statistically significant.The levels of Inflammatory factors CRP,IL-6 and anxiety level were positively correlated.Conclusion:Serum levels of CRP and IL-6 in the elderly CHD patients with anxiety are higher than those in the elderly CHD patients without anxiety,and associated with anxiety.