丁螺环酮对广泛性焦虑症患者情绪图片认知偏倚的影响

目的:探讨丁螺环酮对广泛性焦虑症患者情绪图片信息认知偏倚的影响。方法:选择符合中国精神障碍分类与诊断标准第3版广泛性焦虑症诊断标准的30例患者作为研究组,30名与研究组性别、年龄匹配的健康人作为对照组。研究组给予丁螺环酮治疗8周。两组分别在治疗前和治疗8周后进行情绪图片刺激的点探测任务检测,比较治疗前后反应时以及注意偏向分差别,同时采用汉密尔顿焦虑量表(HAMA)评定疗效。结果:研究组治疗8周后HAMA评分(7.29±1.56)分明显低于治疗前(16.93±2.11)分(t=3.326,P=0.003)。重复测量ANOVA显示,探测位置主效应显著,异侧位置的反应时长于同侧位置(P<0.05);情绪面孔图片类型与组间水平交互作用显著(P=0.000);探测位置与组间水平交互作用显著(P=0.000);情绪面孔图片类型与探测位置交互作用显著(P=0.024);情绪面孔图片类型×探测位置×组间水平交互作用显著(P=0.002);LSD两两比较显示研究组对恐惧面孔图片异侧位置的反应时长于同侧位置(P=0.001)。研究组治疗8周后对恐惧面孔图片反应时以及注意偏向分明显低于治疗前(P=0.006)。结论:广泛性焦虑症患者对恐惧面孔图片信息表现出认知偏倚,丁螺环酮可能具有改善认知偏倚的作用。

Effect of buspirone treatment on cognitive bias to the emotional facial information in generalized anxiety disorder

Objective:To investigate the effect of buspirone treatment on cognitive bias to the emotional facial information in patients with generalized anxiety disorder(GAD).Method:30 patients met Chinese classification of mental disorders and diagnostic criteria-3 for GAD were enrolled as research group and 30 gender,age matched healthy persons enrolled as control group.Patients were treated with buspirone for 8weeks.All participants measured with dot-probe task of emotional facial information at base and after 8 weeks.Reaction times(RTs) and attentional bias scores were compared respectively.Results:After 8 weeks,HAMA scores in research group were lower than that at base(7.29±1.56 Vs.16.93±2.11)(t=3.326,P=0.003).A repeated measure ANOVA revealed a significant probe site main effect,reaction times of antarafacial site were longer than that of homonymy site(P<0.05).It revealed a significant probe site and group interaction(P=0.000),a significant emotional facial information type and probe site interaction(P=0.000),and a significant emotional facial information type×probe site×group interaction(P=0.002).LSD test showed that RTs of antarafacial site to fear facial information in research group were longer than that of homonymy site(P=0.001).RTs and attention bias scores of antarafacial site to fear facial information after 8 weeks in research group were lower than that at base(P=0.006).Conclusion:Patients with GAD had the cognitive bias to the fear facial emotional stimulus.Buspirone treatment might improve the cognitive bias.