血清ICAM-1浓度与冠脉侧支循环形成与否的关系

目的:检测冠脉严重狭窄的冠心病患者的血清ICAM-1浓度,探讨ICAM-1浓度与冠脉侧支循环形成与否的相关性。方法:通过冠脉造影检查,收集主要冠脉至少一支狭窄程度在95%以上的108例冠心病患者,测定其血清ICAM-1浓度。采用Rentrop方法对冠脉侧支循环进行分级,0级为侧支循环未形成组(n=47),1～3级为侧支循环形成组(n=61)。结果:与侧支循环形成组(243.08±70.90 ng/ml)相比,侧支循环未形成组血清ICAM-1浓度(286.38±56.27 ng/ml)明显增高,差异有统计学意义(P=0.001,P<0.01)。结论:冠脉严重狭窄的冠心病患者血清ICAM-1浓度与冠脉侧支循环形成呈负相关。

Correlation between levels of serum ICAM-1 and the for mation of coronary collateral circulation

Objective To investigate the relationship between the levels of serum intercellular adhesion molecules-1(ICAM-1) and the formation of coronary collateral circulation in patients with severe coronary artery stenosis.Method Total 108 patients with at least the stenosis of one vessel ≥95% among three main vessels of coronary artery were consecutively enrolled in the study according to angiographic estimation.Development of collaterals was classified by Rentrop′s method.According to the collateral degree,patients were divided into two groups(a non-CCC formation group:47 patients with grade 0;a CCC formation group:61 patients with grade 2-3).The serum levels of ICAM-1 were also measured.Results Compared with the CCC formation group(243.08±70.90) ng/ml,the levels of serum ICAM-1 with non-CCC formation group(286.38±56.27) ng/ml were increased significantly(P=0.001,P<0.01).Conclusion In patients with severe coronary artery stenosis,the serum levels of ICAM-1 are negatively correlated with CCC formation.