碳酸锂、丙戊酸钠及奎硫平对双相障碍患者认知功能的影响

目的:探讨碳酸锂,丙戊酸钠和奎硫平对双相障碍患者认知功能的影响。方法:110例稳定期双相障碍I型患者分成4组,分别是碳酸锂组26例,丙戊酸钠组24例,碳酸锂+奎硫平组27例和丙戊酸钠+奎硫平组33例。采用数字符号,连线测验,数字广度,视觉再生,言语流畅性测验,威斯康星卡片分类测验(WCST)和汉诺塔检测认知功能,比较组间认知功能的差异。结果:Spearman相关分析显示,病程与所有认知功能指标均无显著相关(P均>0.05)。方差分析显示,汉诺塔计划时间组间差异有统计学意义(F=3.5,P<0.05)。LSD检验表明,碳酸锂组的汉诺塔计划时间成绩分别比丙戊酸钠组,碳酸锂+奎硫平组和丙戊酸钠+奎硫平组差,差异有统计学意义(P<0.05)。结论:碳酸锂可能对稳定期双相障碍患者的某些执行功能有损害。

The effects of lithium carbonate, valproate and quetiapine on cognitive function of patients with bipolar disorder

Objective:To investigate the effects of lithium carbonate,valproate and quetiapine on cognitive function of patients with bipolar disorder.Method:A total of 110 bipolar I disorder patients in stable state were recruited and randomly assigned to 4 groups according to the treatment of drugs:26 patients with lithium carbonate,24 patients with valproate,27 patients with lithium carbonate + quetiapine and 33 patients with valproate + quetiapine.Digital symbol,trail making test,digit span,visual reproduction,verbal fluency test,Wisconsin card sorting test(WCST) and tower of Hanoi test were used to evaluate cognitive function,then the differences between groups were compared.Results:Spearman correlation analysis showed that course of disease and all the indicators of cognitive function were not significantly related(P>0.05).The single factor analysis of variance found that only the difference of tower of Hanoi planning time was statistically significant between the groups(F=3.5,P<0.05).LSD test showed that tower of Hanoi planning time of lithium carbonate group were less than the other groups,and the difference was statistically significant(P<0.05).Conclusion:Lithium carbonate may impaire some executive function in patients of stable bipolar disorder.