伴与不伴广泛性焦虑障碍女性单相抑郁症患者的研究

目的:探讨伴与不伴广泛性焦虑障碍(GAD)中国汉族女性单相抑郁症患者的临床特点、发病次数和影响因素等方面的差异。方法:由受过CONVERGE团队至少1周访谈培训的访谈员,用电脑评估系统对1970例年龄30～60岁女性单相抑郁患者进行访谈,访谈内容包括精神病理学、人口学、个性特点和心理社会功能评估等;有关精神病理学诊断的量表采用综合国际诊断访谈(CIDI,WHO版本2.1,中国版)和美国精神障碍诊断与统计手册第3版(DSM-III修订本),其他量表则采用CONVERGE团队翻译和修正的源于VATSPSUD的工具。结果:单相抑郁伴发GAD的比率较高(68%);伴发GAD的抑郁症患者初次发病年龄较小,且发病次数多,病情重,更多地伴有生物学症状以及神经质的比率较高(P<0.001);但发病次数≥10次,则发病的年龄与次数无明显差异(P>0.05)。伴与不伴GAD在亲情关系方面则与父亲的温情及母亲的保护有关(P=0.007,0.035);而与受教育程度、职业类别无关(P>0.05)。结论:女性单相抑郁症与GAD有较高的相关度。

The relative study of female unbipolar depression with and without general anxiety disorder in China

Objective:To explore the difference of Han female major depression patients with and without general anxiety disorder(GAD) in clinical characteristics,episode and affecting factors on GAD or not.Method:1 970 cases of female major depression(MD) aged between 30 and 60 were interviewed using a computerized assessment system.All interviews were trained by CONVERGE team for a minimum of one week in the use of the interview.The interview component included assessment of psychopathology,demographic,personal characteristic and psychosocial functioning.The diagnoses about psychopathology were established by composite international diagnostic interview(CIDI) and diagnostis and statistical manual of mental disorders-III-R.The other assessment implements were translated by the CONVERGE team from the VATSPSUD.Results:The percent of MD with GAD is higher than without GAD(68%),the age of first episode of MD with GAD is smaller,the episode of MD with GAD is more frequent,more serious and with more biological symptoms.The nervous proportion is also higher(P<0.001).But if episode number of times ≥10,these were not obvious difference(P>0.05).Major depression patients with and without GAD were all presented warmth relationship between parents and children,which is connected father warmth or mother protectiveness(P=0.007,P=0.035).Education and occupation show no significant difference between MD with GAD or without GAD.Conclusion:Female major depression is related severely with GAD.