耐甲氧西林溶血葡萄球菌感染情况调查及药敏分析

目的:为了解本院耐甲氧西林溶血葡萄球菌感染情况和耐药特点。方法:回顾性分析2009年11月~2011年10月期间87株耐甲氧西林溶血葡萄球菌感染情况及耐药性特点。结果:在这2年期间耐甲氧西林溶血葡萄球菌(MRSH)检出率为97.8%(87/89),科室分布以重症监护室为最多18.4%(16/87),其次是新生儿科16.1%(14/87);其主要来源于伤口标本44.8%(39/87),其次是血液标本24.1%(21/87)。按年份分组比较分析,MRSH检出率由100.0%(49/49)降到95.0%(38/40);其对克拉霉素、阿奇霉素和红霉素的耐药性增强,且均大于83.0%,对四环素、利福平和克林霉素的耐药性降低,对万古霉素、利奈唑烷和替加环素均敏感。结论:溶血葡萄球菌感染以MRSH菌居多,且对常用抗菌药物均有较高的耐药性,MRSH的医院感染和社区感染均比较严重,应加强对MRSH的监测及防控。

Survey on methicillin-resistant staphylococcus haemolyticus infection and analysis of drug susceptibility

Objective To investigate methicillin-resistant staphylococcus haemolyticus(MRSH)infection and drug-resistance.Methods The survey was conducted over a period of 24 months between Nov 2009 and Oct 2011 in our hospital.A total of 87 cases of methicillin-resistant staphylococcus haemolyticus infection were analysed and performed with drug sensitivity test.Results The detection rate of MRSH among all the isolated strains is 97.8%(87/89)in our hospital during the two-year period.18.4%(16/87)is from intensive care unit(ICU),16.1%(14/87)is from newborn department.44.8%(39/87)is from wound specimens.24.1%(21/87)is from blood specimens.the detection rate of MRSH decreased from 100.0%(49/49)to 95.0%(38/40).Meanwhile,the resistance rates of the MRSH to the antibiotics(Sulfamethoxazole/Trimethoprim clarithromycin,azithromycin,erythromycin,)were increased,whereas for the antibiotics(gentamicin,tetracycline,ciprofloxacin,levofloxacin,oxifloxacin,clindamycin)the resistance rates were decreased.They were all sensitive to vancomycin,linezolid and tigecycline.Conclusion Staphylococcus haemolyticus infections are mostly MRSH.Its antibiotic resistance to Common antibiotics was serious.The Hospital infection rate and community infection rate of MRSH were serious.It should be gave more monitoring,Prevention and control.