辛伐他汀对维持性血液透析患者微炎症状态的影响

目的观察辛伐他汀对维持性血液透析患者微炎症状态的影响，探讨他汀类药物在治疗尿毒症患者微炎症状态中的作用。方法选择我院维持性血液透析患者60例，随机分为辛伐他汀治疗组和非辛伐他汀治疗组各30例。2组患者于治疗前，治疗后6个月检测高敏-C反应蛋白（hs-CRP）、白介素-6（IL6）、肿瘤坏死因子-α（TNF-α）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）水平；同时设42例健康者为健康对照组。结果①维持性血液透析患者hs—CRP、IL-6、TNF-α、TG水平显著高于健康对照者（P〈0．01），HDL水平明显低于健康对照者（P〈0．05）；②治疗6个月后，辛伐他汀治疗组hs—CRP、IL-6、TNF-α、TG、TC、LDL的水平均有所下降，HDL升高，辛伐他汀治疗组hs—CRP、IL-6、TNF-α、TG、TC、LDL下降的水平与治疗前及非辛伐他汀治疗组相比，差异显著（P〈0．05）。结论辛伐他汀治疗能显著改善尿毒症患者的脂质代谢，同时改善患者的微炎症状态。

Therapeutic effect of Simvastatin on microinflammation in patients subject to maintenance hemodialysis

Objective To investigate the effects of Simvastatin on microtnflammatorg state in patients with uremia undergoing maintenance hemodialysis. Methods In 60 patients undergoing maintenance hemodialysis and 42 healthy control subjects the levels of high-sensitivity C-reactive protein （hs-CRP）, interlukin-6 （IL-6）, tumor necrosis factor alpha （TNF-α）, and serum lipid were determined. The patients were randomly divided into 2 groups, receiving Simvastatin （ 10 mg daily） or non Simvastatin therapy respectively. All parameters were assayed again after 6 months. Results Compared with healthy people, serum hs-CRP, IL-6, TNF-α, and TG levels were significantly higher in Simvastatin-treated group. Six months after treatment, the levels of serum hs-CRP, IL-6, TNF-α, TG, TC, and LDL in Simvastatin-treated group were lower than before （P〈0. 05）, while serum HDL was higher. The levels of h-CRP, IL-6, TNF-α, TG, TC and LDL were significantly lower in Simvastatin-treated group than in non-Simvastatin-treated group （P〈0. 05）. Conclusions Simvastatin can significantly improve serum lipid metabolism, alleviate the microinflammation state in patients with uremia subject to maintenance hemodialysis.