益气养阴活血方联合前列地尔治疗糖尿病肾病

目的　探讨益气养阴活血方联合前列地尔治疗 2型糖尿病并发肾病的临床疗效。方法　 4 0例糖尿病肾病 (DN)患者随机分为治疗组与对照组 ,两组使用诺和龙或诺和灵、拜糖平良好控制血糖 ,ACEI或联合CCB良好控制血压 ,在此基础上治疗组加用中药益气养阴活血方口服 ,同时联合前列地尔 10 μg加入生理盐水 10 0ml中静脉滴注 ,两组疗程均为 1个月 ,治疗 1个疗程后观察 2 4h尿蛋白排泄量、尿三蛋白定量以及血液流变学的变化。结果　总有效率治疗组 90 % ,对照组 5 5 % ,两组比较差异有显著意义 (P <0 0 5或P <0 0 1) ,治疗组在减少 2 4h尿蛋白定量、尿蛋白的排泄率及改善血液流变学方面明显优于对照组。结论　益气养阴活血方联合前列地尔是治疗 2型糖尿病并发肾病的有效方法之一

Treatment of diabetic nephropathy with "Yiqi,yangyin,huoxue" and "Alprostadil"

Objective To study the clinic efficacy of “Yiqi,yangyin,huoxue” combinated with “Alprostadil” on diabetic nephropathy.Methods Fourty patients with diabetic nephropathy were randomly divided into 2 groups,and all patients received the treatment of repaglinide or novolin,glucobay,ACEI and CCB to control blood sugar and blood pressure.Additionly,the experimental group(20 cases) received the “Yiqi,yangyin,huoxue” and intravenous drips of “Alprostadil”(10μg daily) for 1 month.Urine protein excretion and hemorheology were tested for all cases before and after treatment.Results The effective rates in experiment group and control group were 90% and 55% respectively(P<0.05),the efficacy of experiment group on urine protein excretion and hemorheology were better than those of control group significantly.Conclusion Our data suggests that the combination of “Yiqi,yangyin,huoxue” and “Alprostadil” is an effective treatment for diabetic nephropathy.