慢性阻塞性肺疾病急性加重期血清CRP与动脉血气联合检测的临床意义

目的:探讨C反应蛋白(C reaction protein,CRP)和动脉血气检测在慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的临床意义及临床应用价值。方法:45例确诊为AECOPD患者分别于治疗前、后测定动脉血气与血清CRP水平,并与35例正常对照者比较。采用免疫比浊法测定CRP,i-STAT血气分析仪进行血气分析。结果:AECOPD患者治疗前、后CRP水平均显著高于正常对照组(P<0.01);PaO₂治疗后较治疗前显著上升(P<0.01);PaCO₂治疗后较治疗前显著下降(P<0.01)。结论:CRP升高不仅可以提示慢性阻塞性肺疾病(COPD)的急性加重,联合动脉血气检测还是AECOPD一个良好的疗效观察和预后判断指标。患者的严重感染合并低氧血症、CO₂潴留提示COPD患者病情严重并很可能预后不良。CRP与动脉血气联合检测不仅是患者病情判断的指标,也为临床疗效评估提供一定的实验室依据。

Clinical significance of detecting C reaction protein and arterial blood-gas analysis in patients at the acute exacerbation of chronic obstructive pulmonary disease

Objective：To explore the clinical value of detecting C reaction protein（CRP）and arterial blood-gas analysis（ABG）in patients at the acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods：The levels of CRP and ABG in 45 patients with AECOPD were detected before and after treatment,and the results were compared with those of 35 controls.CRP was determined with immune turbidimetry method,and ABG was detected by i-STAT blood-gas analyzer＇s performance.Results：The serum concentration of CRP of the AECOPD patients was higher than that of the control before and after treatment（P〈0.01）.After treatment,PaO2 in AECOPD patients increased significantly,while PaCO2 decreased（P〈0.01）.Conclusions：There are obvious changes of the serum concentrations of CRP,ABG in AECOPD patients before and after treatment.Serum concentration of CRP and ABG may act as indicators of curative effect and prognosis,which will provide some laboratory evidence for clinical assessment.