甲钴胺对老年糖尿病周围神经病变患者平衡功能的影响

目的观察甲钴胺对老年糖尿病周围神经病变（DPN）患者平衡功能的影响。方法老年2型糖尿病合并DPN患者56例，随机分为两组，每组28例。治疗组给予肌注甲钴胺500μg，1次/天，对照组给予肌注维生素B1100mg＋维生素B120．5mg，1次／天，共治疗8周。治疗前后运用Berg平衡量表（BBS）评价患者平衡功能。结果治疗组BBS评分8周后较治疗前显著提高（P〈0．05），治疗前后BBS评分变化比较两组有显著性差异（P〈0．01）。结论甲钴胺能有效改善老年DPN患者的平衡功能。

Effect of mecobalamin on the balance ability in older patients with diabetic peripheral neuropathy

Objective To observe the effect of mecobalamin on the balance ability in older patients with diabetic peripheral neuropathy（DPN）. Methods Older patients with DPN （n = 56）were randomly divided into two groups：treatment group （n = 28）received daily mecobalamin 500 μg i. m and control group（ n = 28 ） received VitB1 100 nag ＋ VitB12 0.5 mg i. m ,both for 8 weeks. To evaluate Berg Balance Scale（BBS）scores pretheraphy and 8 weeks late. Results In treatment group BBS scores 8 weeks late were significantly improved compare to pretheraphy（ P 〈0.05） ,the scores change between two groups was significantly statistical difference（ P 〈 0. 01 ）. Conclusion Mecobalamin can effectively improve the balance ability in older patients with DPN.