| p(3HB-co-3HH)/PU生物可降解支架材料生物相容性的研究 |
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| 引用本文： | 高峰,胡平,周建业,胡盛寿. p(3HB-co-3HH)/PU生物可降解支架材料生物相容性的研究[J]. 北京生物医学工程, 2006, 25(3): 300-303,324 |
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| 作者姓名： | 高峰 胡平 周建业 胡盛寿 |
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| 作者单位： | 首都医科大学附属北京安贞医院心外科,北京,100029;清华大学化工系高分子所,北京,100084;中国医学科学院阜外心血管病医院心外科,北京,100037 |
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| 摘 要： | 对生物可吸收材料p(3HB-co-3HH)/PU共聚多聚体的生物相容性进行评估.材料与方法分别采用体外细胞毒性试验(直接接触法和MTT法),皮下植入试验来评价p(3HB-co-3HH)/PU生物可降解支架材料的局部组织反应.结果犬股静脉肌成纤维细胞在p(3HB-co-3HH)/PU薄膜涂附的玻片上及其浸提液中均生长良好,皮下植入显示仅引起轻度的炎症反应.结论p(3HB-co-3HH)/PU共聚多聚体材料具有较好的生物相容性.
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| 关 键 词： | 生物可降解 生物相容性 支架 |
| 文章编号： | 1002-3208（2006）03-0300-04 |
| 收稿时间： | 2005-07-22 |
| 修稿时间： | 2005-07-22 |
Study for the Biocompatibility of p (3HB-co-3HH) /PU Biodegradable Scaffold |
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| GAO Feng,HU Ping,ZHOU Jianye,HU Shengshou. Study for the Biocompatibility of p (3HB-co-3HH) /PU Biodegradable Scaffold[J]. Beijing Biomedical Engineering, 2006, 25(3): 300-303,324 |
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| Authors: | GAO Feng HU Ping ZHOU Jianye HU Shengshou |
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| Affiliation: | 1.Belling Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029; 2. Chemical Engineering Department, Tsinghua University, Beijing 100037 ; 3. Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences, Belling 100037 |
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| Abstract: | Objective To evaluate the biocompatibility of p(3HB-co-3HH)/PU-A new biodegradable co-polymer scaffold.Methods Tests in vitro and in vivo were completed to evaluate the biocompatibility of the p(3HB-co-3HH)/PU patch.The test in vitro included MTT assay and direct-contacted methods,and the test in vivo was subcutaneous implant and aorta replacement test.Results The myofibroblasts growed well on the glass slide covered with membrane of p(3HB-co-3HH)/PU and in the solution of p(3HB-co-3HH)/PU.The patches implanted mouse subcutaneous only caused slight inflammation.Conclusion The new biodegradable copolymer scaffold,p(3HB-co-3HH)/PU,had a good biocompatibility. |
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| Keywords: | biodegradable biocompatibility scaffold |
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