增殖诱导配体在非小细胞肺癌组织中的表达与临床意义

目的:探讨增殖诱导配体(APR IL)mRNA在非小细胞肺癌的表达及临床意义。方法:采用荧光定量聚合酶链反应技术检测肺癌组织、癌旁组织及正常肺组织标本中APR IL mRNA的表达情况,其结果与临床病理指标进行分析。结果:APR IL mRNA在肺癌组织中表达最高,癌旁组织次之,正常肺组织最低(P<0.05)。且APR IL mRNA表达水平与肿瘤细胞分化程度、淋巴结远处转移及TNM分期相关(P<0.05),但与患者的性别、年龄、肺癌肿块大小和病理细胞类型无关(P>0.05)。结论:APR IL在肺癌发生和促进其淋巴结远处转移的过程中具有重要功能。

The expression of APRIL and its clinical significance in nonsmall - cell lung cancer tissues

Objective:To explore the expression of APRILmRNA and its clinical significance in nonsmall-cell lung cancer.Methods:Fluorescence quantitative PCR(RFQ-PCR)was used to measure the APRILmRNA expression in the primary tumor tissues,para-cancer tissues and normal tissues,and to analyse their results and results clinical and pathological indexes.Results:APRILmRNA expression level was the highest in the primary tumor tissues compared with the others,followed by para-cancer tissues,with normal tissues last(P<0.05).And APRILmRNA expression level was closely associated with cell differentiation grade,lymph node metastasis and TNM stage of nonsmall-cell lung cancer(P<0.05),but not with the tumour size,the pathological cell types or gender and age of patients(P>0.05).Conclusion:APRIL plays an important role in the malignant progression and lymph node metastasis of nonsmall-cell lung cancer.