CD10在甲状腺疾病中的表达及意义

目的研究CD10在甲状腺疾病中的表达及意义。方法收集70例甲状腺良、恶性病变组织，其中15例滤泡性腺瘤、15例腺瘤性甲状腺肿、30例乳头状癌和10例滤泡性癌。采用免疫组织化学的方法检测CD10在上述病变中的表达。结果9例滤泡型乳头状癌中，7例表达CD10，CD10阳性率为77％。10例滤泡性癌中，8例表达CD10，阳性率为80％。而在滤泡性腺瘤和腺瘤性甲状腺肿及21例普通型乳头状癌组织中CD10均不表达。CD10在滤泡型乳头状癌和滤泡性癌中的阳性率显著高于滤泡性腺瘤和腺瘤性甲状腺肿中的阳性率（P〈0．01）。结论对CD10表达的检测有助于对甲状腺滤泡性癌和滤泡型乳头状癌的诊断。

CD10 expression in the thyroid disease and significance

Objective To investigate the role of CD10 expression in the differential diagnosis of thyroid diseases.Methods In 70 cases of thyroid lesions (including 15 cases of follicular adenomas,15 cases of adinomatous goiters,30 cases of papillary carcinomas and 10 cases of follicular carcinomas),the CD10 expression was detected by means of immunohistochemistry.Results Seven of 9 cases of follicular variant of papillary carcinoma were CD10 positive (77%),and 8 of 10 cases of follicular carcinomas were CD10 positive (80%).CD10 was negative in all cases of follicular adenoma and adinomatous goiter and normal papillary carcinomas.The positive incidence of CD10 in papillary carcinomas and follicular variant of papillary carcinoma was significantly higher than that in follicular adenoma and adinomatous goiter(P<0.01).Conclusion The detection of CD10 expression is useful to the differential diagnosis of thyroid follicular carcinomas and follicular variant of papillary carcinomas.