KY-62, a Polyene Analog of Amphotericin B, for Treatment of Murine Candidiasis |
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| Authors: | John R. Graybill Laura K. Najvar Annette Fothergill Thomas Hardin Michael Rinaldi Chris Lambros Steven L. Regen |
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| Affiliation: | University of Texas Health Science Center1. and South Texas Veterans Health Care System,2. San Antonio, Texas 78284; Lehigh University, Bethlehem, Pennsylvania 180153.; and National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 208924. |
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| Abstract: | KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development. |
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