Factors related to clinically probable REM sleep behavior disorder in Parkinson disease |
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| Institution: | 1. Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea;2. Department of Neurology, National Health Insurance Corporation Hospital,1232 Baeksuk-dong, Ilsandong-gu, Goyang 410-719, Republic of Korea;3. Department of Neurology, Parkinson/ Alzheimer Center, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea;1. Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea;2. McGill Center for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Canada;3. Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;4. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;5. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea;1. Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway;2. Department of Neurology, Oslo University Hospital–Rikshospitalet, Oslo, Norway;3. Faculty of Medicine, University of Oslo, Oslo, Norway;1. Neurology Department Hospital de Egas Moniz (CHLO), Lisboa, Portugal;2. Departamento de Neurologia, CEDOC, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal |
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| Abstract: | Rapid eye movement sleep behavior disorder (RBD) is commonly accompanied in Parkinson disease (PD). However, the underlying mechanism linking RBD to PD remains unclear. We interviewed and examined 447 consecutive patients with PD to investigate factors associated with the presence of RBD in PD patients. Using the minimal diagnostic criteria for parasomnias provided in the International Classification of Sleep Disorders-Revised (ICSD-R), 164 patients (36.5%) were diagnosed with clinically probable RBD (cpRBD). PD patients with cpRBD were older, had a longer duration of PD, a more severe level of disability, a longer duration of antiparkinsonian medication, and a lower proportion of their Unified Parkinson Disease Rating Scale (UPDRS) scores accounted for by tremor than those without RBD. Multivariate and univariate logistic regression analyses revealed that patient age, PD symptom duration (and, accordingly, more severe motor disability), tremor score, and proportion of the UPDRS score accounted for by tremor were significant factors associated with the presence of RBD in PD patients. The results of the present study support previous observations that PD with RBD may result from a different underlying pattern of neurodegeneration than PD without RBD. |
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