运动对慢性阻塞性肺疾病系统性炎症和骨骼肌功能障碍干预效果的系统综述

目的 系统综述运动对慢性阻塞性肺疾病(COPD)系统性炎症及骨骼肌功能障碍的干预效果。方法 检索建库至2021年6月PubMed、Web of Science、CNKI、维普和万方数据,运动对COPD系统性炎症及骨骼肌功能障碍干预效果的相关文献,并辅以参考文献回溯和手工检索。提取文献内容,对运动改善COPD系统性炎症及骨骼肌功能障碍的效果进行综述。结果 共检索到文献192篇,最终纳入8篇,245例被试。运动可以降低促炎因子水平,提高抗炎因子水平;提高COPD患者运动能力,改善骨骼肌结构。运动改善COPD系统性炎症与运动方式、强度以及持续时间有关,可能通过调控炎症反应,影响泛素-蛋白酶、胰岛素样生长因子1/磷脂酰肌醇-3-激酶/Akt等途径,改善骨骼肌功能障碍。结论 运动对降低COPD系统性炎症水平、改善骨骼肌功能障碍具有一定效果。

Effect of Exercise on Chronic Obstructive Pulmonary Disease Systemic Inflammation and Skeletal Muscle Dysfunction: A Systematic Review

Objective To systematically review the effects of exercise on systemic inflammation of chronic obstructive pulmonary disease (COPD) and skeletal muscle dysfunction.Methods The literature about the effect of exercise on COPD systemic inflammation and skeletal muscle dysfunction were retrieved from PubMed, Web of Science, CNKI, VIP and Wanfang data, until June, 2021, supplemented by reference review and manual retrieval.Results A total of 192 literatures were retrieved and eight were included, involving 245 subjects. The comprehensive results showed that exercise could decrease the level of pro-inflammatory factors and increase the level of anti-inflammatory factors. Exercise can improve the motor ability and skeletal muscle structure of patients with COPD. Exercise can improve systemic inflammation of COPD, which is related to the mode, intensity and duration of exercise. Exercise may affect ubiquitin-protease, insulin-like growth factors -1/phosphatidylinositol 3 kinase/Akt and other pathways by regulating the inflammatory response, and improve skeletal muscle dysfunction.Conclusion Exercise has certain effect on reducing systemic inflammation and improving skeletal muscle dysfunction.