Effects of short-term overfeeding with fructose,fat and fructose plus fat on plasma and hepatic lipids in healthy men |
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| Affiliation: | 1. Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 7, rue du Bugnon, 1005 Lausanne, Switzerland;2. Department of Clinical Research, University of Bern, Pavillon 52A, Inselspital, P.O. Box 35, 3010 Bern, Switzerland;3. Service of Endocrinology, Diabetes and Metabolism, CHUV, Lausanne, Switzerland |
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| Abstract: | AimsThe present study aimed to assess the effects of excess fat, fructose and fat-plus-fructose intakes on intrahepatocellular lipid (IHCL).MethodsHealthy male subjects were studied after an isocaloric diet or a 7-day high-fructose (Fru: +3.5 g fructose/kg fat-free mass/day, +35% energy), high-fat (Fat: +30% energy as saturated-fat) or high-fructose, high-fat diet (FruFat: +3.5 g fructose/kg fat-free mass/day, +30% energy as fat, +65% total energy). IHCL was measured by 1H magnetic resonance spectroscopy.ResultsAll hypercaloric diets increased IHCL (Fru: +16%; Fat: +86%; FruFat: +133%; P < 0.05). Very low-density lipoprotein (VLDL) triacylglycerols increased after Fru (+58%; P < 0.05), but decreased after Fat (−22%; P < 0.05), while no change was observed after FruFat.ConclusionFat and fructose both increased IHCL, but fructose increased, while fat decreased, VLDL triacylglycerols. However, excess fat and fructose combined had additive effects on IHCL and neutralizing effects on VLDL triglycerides. This suggests that fructose stimulates, while fat inhibits, hepatic VLDL triacylglycerol secretion. |
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