Liver function in COVID-19 infection |
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Authors: | Dagmara Przekop Ewa Gruszewska Lech Chrostek |
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Institution: | Dagmara Przekop, Diagnostics-Experimental Center of Sexually Transmissible Diseases, Bialystok 15-879, PolandEwa Gruszewska, Lech Chrostek, Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok 15-269, Poland |
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Abstract: | Coronavirus disease 2019 (COVID-19) disease affects multiple organs, including anomalies in liver function. In this review we summarize the knowledge about liver injury found during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with special attention paid to possible mechanisms of liver damage and abnormalities in liver function tests allowing for the evaluation of the severity of liver disease. Abnormalities in liver function observed in COVID-19 disease are associated with the age and sex of patients, severity of liver injury, presence of comorbidity and pre-treatment. The method of antiviral treatment can also impact on liver function, which manifests as increasing values in liver function tests. Therefore, analysis of variations in liver function tests is necessary in evaluating the progression of liver injury to severe disease. |
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Keywords: | COVID-19 Pathogenesis of liver injury Angiotensin-converting enzyme 2 receptor Liver function tests Severe COVID-19 Treatment effect |
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