2型糖尿病患者甲状腺激素及抗体水平变化研究

背景　近年来，临床上发现2型糖尿病患者甲状腺激素的改变和抗体升高的现象多于非糖尿病人群，而真正危害2型糖尿病患者身心健康的正是其多种并发症及合并症，考虑到甲状腺疾病对人体的危害同样重大，由此引发了对2型糖尿病患者甲状腺激素和抗体改变的思考。目的　探讨2型糖尿病患者甲状腺激素及抗体水平的变化情况。方法　选取2018年4月-2019年3月中国医科大学附属第一医院全科医学科收治的172例2型糖尿病患者作为2型糖尿病组，同时选取160例非糖尿病患者作为对照组。收集患者性别、年龄、糖尿病病程、糖化血红蛋白（HbA1c）水平、高血压病史、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）等指标，并测定甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）、促甲状腺素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）水平。再根据糖尿病病程，将糖尿病患者分为病程<1年组（19例）、1~10年组（69例）、>10年组（84例）；根据HbA1c水平，将糖尿病患者分为HbA1c≤6.5%组（67例）、6.5%10年组TGAb水平高于<1年组，>10年组FT3水平低于1~10年组（P<0.05）。不同HbA1c水平糖尿病组TGAb水平比较，差异有统计学意义（P<0.05）；其中6.5%

Abnormal Changes of Serum Thyroid Hormones and Antibodies in Type 2 Diabetic Patients

Background　The prevalence of abnormal changes of thyroid hormones and elevated thyroid antibodies has been recently found to be higher in type 2 diabetics than that of non-type 2 diabetics.As thyroid disease-induced harm on physical health in the real world is similar to that of diabetes-related complications and comorbidities in type 2 diabetics，treating diabetes via improving abnormal changes of thyroid hormones and antibodies has become a concern issue.Objective　To explore the abnormal changes of serum thyroid hormones and antibodies in type 2 diabetics.Methods　172 type 2 diabetics（type 2 diabetes group） were recruited from Department of General Medicine，the First Hospital of China Medical University from April 2018 to March 2019，and were compared to 160 non-type 2 diabetics（control group）.Data were collected，including gender，age，duration of diabetes，HbA1c，history of hypertension，TC，TG，LDL，HDL，TPOAb，TGAb，TSH，FT3，and FT4.Thyroid hormones and antibodies were compared between diabetics and control groups，and were compared between the diabetics by duration of type 2 diabetes〔<1 year（n=19），1-10 years（n=69），>10 years（n=84）〕，HbA1c〔≤6.5%（n=67），6.5%