Liver manifestations and complications in inflammatory bowel disease: A review |
| |
Authors: | Rui Gaspar Catarina Castelo Branco Guilherme Macedo |
| |
Affiliation: | Rui Gaspar, Guilherme Macedo, Department of Gastroenterology and Hepatology, Centro Hospitalar de São João, Porto 4200, PortugalCatarina Castelo Branco, Internal Medicine Department, Centro Hospitalar e Universitário do Porto, Porto 4200, Portugal |
| |
Abstract: | Hepatobiliary manifestations are common in inflammatory bowel disease (IBD), with 30% of patients presenting abnormal liver tests and 5% developing chronic liver disease. They range from asymptomatic elevated liver tests to life-threatening disease and usually follow an independent course from IBD. The pathogenesis of liver manifestations or complications and IBD can be closely related by sharing a common auto-immune background (in primary sclerosing cholangitis, IgG4-related cholangitis, and autoimmune hepatitis), intestinal inflammation (in portal vein thrombosis and granulomatous hepatitis), metabolic impairment (in non-alcoholic fatty liver disease or cholelithiasis), or drug toxicity (in drug induced liver injury or hepatitis B virus infection reactivation). Their evaluation should prompt a full diagnostic workup to identify and readily treat all complications, improving management and outcome. |
| |
Keywords: | Hepatobiliary manifestations Inflammatory bowel disease Drug induced liver injury Primary sclerosing cholangitis Viral hepatitis Crohn's disease Ulcerative colitis |
|
| 点击此处可从《World journal of hepatology》浏览原始摘要信息 |
|