Cellular factors involved in the hepatitis C virus life cycle |
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Authors: | Hui-Chun Li Chee-Hing Yang Shih-Yen Lo |
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Affiliation: | Hui-Chun Li, Department of Biochemistry, Tzu Chi University, Hualien 970, TaiwanChee-Hing Yang, Shih-Yen Lo, Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien 970, TaiwanShih-Yen Lo, Department of Laboratory Medicine, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan |
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Abstract: | The hepatitis C virus (HCV), an obligatory intracellular pathogen, highly depends on its host cells to propagate successfully. The HCV life cycle can be simply divided into several stages including viral entry, protein translation, RNA replication, viral assembly and release. Hundreds of cellular factors involved in the HCV life cycle have been identified over more than thirty years of research. Characterization of these cellular factors has provided extensive insight into HCV replication strategies. Some of these cellular factors are targets for anti-HCV therapies. In this review, we summarize the well-characterized and recently identified cellular factors functioning at each stage of the HCV life cycle. |
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Keywords: | Hepatitis C virus Cellular factor Viral entry Translation Replication Assembly Release |
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