Subthalamic and red nucleus volumes in patients with Parkinson’s disease: Do they change with disease progression? |
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| Institution: | 1. Department of Neurology, University of Munich at Marchioninistrasse 15, 81377 Munich, Germany;2. INESC TEC (Instituto de Engenharia de Sistemas e Computadores do Porto), University of Porto at Rua Dr. Roberto Frias 4200-465 Porto, Portugal;3. Faculty of Engineering, University of Porto at Rua Dr. Roberto Frias 4200-465 Porto, Portugal;4. Portuguese Brain Imaging Research Network, 3000-548 Coimbra, Portugal;5. IEETA (Instituto de Engenharia Electronica e Telematica de Aveiro), University of Aveiro, Campus Universitário 3810, 3810-193 Aveiro, Portugal;6. Department of Neuroradiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany;7. Department of Neurosurgery, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany;1. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;2. Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States;2. Department of Neurology, Emory University, Atlanta, GA, United States;3. Center for Health Research Southeast, Kaiser Permanente, Atlanta, GA, United States;4. Department of Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany;5. Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States;1. Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan;2. Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan;3. Chemicals Evaluation and Research Institute, Japan, 1-4-25 Koraku, Bunkyo-ku, Tokyo 112-0004, Japan |
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| Abstract: | ObjectiveTo examine a possible correlation between disease progression and the volumes of the subthalamic nucleus (STN) and red nucleus (RN) in patients with Parkinson disease (PD).MethodsTwelve patients with PD (mean time since diagnosis 10.8 ± 2.9 years) and age-matched 12 normal control subjects were enrolled. The volumes of the STN and RN were measured using 3-dimensional volume reconstructions of stereotactic magnetic resonance images.ResultsThe PD and control groups were similar with regard to age and gender. The STN volume was 0.13 ± 0.01 cm3 (mean ± SD) in PD patients and 0.27 ± 0.01 cm3 in controls (P < .001). The RN volume was 0.31 ± 0.02 cm3 in PD patients and 0.21 ± 0.02 cm3 in controls (P = .002). Positive correlations of RN volume with time since diagnosis (P = .004) and disease stage (P = .01) were observed. On average, the STN volumes were 48% smaller and RN volumes 32% larger in PD patients than in control subjects; the volumes of the two nuclei were negatively correlated (r = −0.46; P = .03).ConclusionsOur results suggest that advanced disease stage and longer disease duration are associated with increased RN volume. STN volume was significantly smaller in Parkinson group. These findings may be useful in estimating disease status and rate of progression, and may also have implications for surgical treatment. Larger studies are needed to validate these results and determine their usefulness. |
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