Reduced muscle power is associated with slower walking velocity and falls in people with Parkinson's disease |
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| Institution: | 1. Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;2. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;3. Department of Radiology, Weill Cornell Medical College, New York, USA;1. Chulalongkorn Center of Excellence for Parkinson Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand;2. Department of Rehabilitation Medicine, Juntendo University, Tokyo, Japan;1. University of Miami, Laboratory of Neuromuscular Research and Active Aging, Department of Kinesiology and Sports Sciences, Coral Gables, FL, United States;2. Miller School of Medicine, Center on Aging, University of Miami, Miami, FL, United States;1. Escola Superior da Tecnologia de Saúde do Instituto Politécnico do Porto, Área Científica de Terapia Ocupacional, Centro de Estudo do Movimento e da Atividade Humana, Portugal;2. Faculdade de Engenharia, Universidade do Porto, Portugal;3. Escola Superior da Tecnologia de Saúde do Instituto Politécnico do Porto, Área Científica de Fisioterapia, Centro de Estudo do Movimento e da Atividade Humana, Portugal;4. Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto, Área Cientifica de Terapia Ocupacional, Portugal;5. Escola Superior da Tecnologia de Saúde do Instituto Politécnico do Porto, Área Científica de Terapia Ocupacional, Laboratório de Reabilitação Psicossocial, Centro de Estudo do Movimento e da Atividade Humana, Portugal;6. Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, Departamento de Engenharia Mecânica, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal |
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| Abstract: | PurposeMuscle strength (force) and power (force × velocity) are reduced in Parkinson's disease (PD). Reduced muscle power is associated with slower walking velocity and falls in the older population, but these associations in people with PD have not previously been investigated. This study investigated the relationships between leg extensor muscle power and strength with walking speed and past falls in people with PD.Participants and MethodsForty people with mild to moderate PD were assessed. Walking velocity was measured over 10 m and the number of falls the participant reported having in the past 12 months was recorded. Leg extensor muscle power and strength were measured using a Keiser leg press machine.ResultsMuscle power explained more than half of the variance (R2 = 0.54) in walking velocity and remained significantly (p < 0.05) associated with walking velocity in models which included Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. Participants with low muscle power were 6 times more likely to report multiple falls in the past year than those with high muscle power (OR = 6.0, 95% CI 1.1 to 33.3), though this association between falls and power was no longer significant in models which included UPDRS motor scores (p = 0.09).ConclusionMuscle power is a significant determinant of walking velocity in PD even after adjusting for UPDRS motor score. Muscle power training warrants investigation in people with PD. |
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