Neurological manifestations of hepatitis E virus infection: An overview |
| |
Authors: | Ashish Kumar Jha Gaurav Kumar Vishwa Mohan Dayal Abhay Ranjan Arya Suchismita |
| |
Affiliation: | Ashish Kumar Jha, Gaurav Kumar, Vishwa Mohan Dayal, Department of Gastroenterology, Indira Gandhi Institute of Medical Sciences, Patna 800014, IndiaAbhay Ranjan, Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna 800014, IndiaArya Suchismita, Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Basant Kunj 110070, New Delhi, India |
| |
Abstract: | Hepatitis E virus (HEV) is an important cause of repeated waterborne outbreaks of acute hepatitis. Recently, several extrahepatic manifestations (EHMs) have been described in patients with HEV infection. Of these, neurological disorders are the most common EHM associated with HEV. The involvement of both the peripheral nervous system and central nervous system can occur together or in isolation. Patients can present with normal liver function tests, which can often be misleading for physicians. There is a paucity of data on HEV-related neurological manifestations; and these data are mostly described as case reports and case series. In this review, we analyzed data of 163 reported cases of HEV-related neurological disorders. The mechanisms of pathogenesis, clinico-demographic profile, and outcomes of the HEV-related neurological disorders are described in this article. Nerve root and plexus disorder were found to be the most commonly reported disease, followed by meningoencephalitis. |
| |
Keywords: | Hepatitis E virus Acute hepatitis E Extrahepatic manifestations Neurological manifestations Neuralgic amyotrophy Guillain-Barré syndrome |
|
| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 |
|